Figure 2: The mTOR signaling pathway. mTOR sits at the center of a complex regulatory network that senses the nutrient and growth factor status of the intracellular and extracellular environments, respectively, and transduces that information into growth and proliferative decisions. Pharmacologic inhibition of mTOR delivers the false signal that the cell is starved of nutrients and lacks growth factor stimulation, initiating the cellular starvation response that includes a dramatic metabolic reprogramming, prevention of cell growth and arrest of cell division.

V2N4 ESUN Copyright © 2005 Liddy Shriver Sarcoma Initiative.