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Community physicians - should they refer that lump or bump before intervention? Yes, this is why we have multidisciplinary sarcoma centers! by Prof Ian Judson MD, FRCP Medical Oncologist, Royal Marsden Hospital, London President Connective Tissue Oncology Society, 2007
[Editor's Note: This is the first in the series of Op Ed pieces written by one of the members of the Board of Directors of the Connective Tissue Oncology Society (CTOS). This series was announced in the last issue of ESUN, see, A Milestone. CTOS is the premier international professional medical society for physicians and scientists with a primary interest in the tumors of connective tissues. The goal of the society is to advance the care of patients with connective tissue tumors and to increase knowledge of all aspects of the biology of these tumors, including basic and clinical research. The Op Ed pieces are intended to address important and controversial issues in the field. We will be initiating a “CTOS Counterpoint” column in the next issue of ESUN to allow readers to express their opinions in response to these Op Ed pieces. Click here to send in an opinion.]
Lumps are common, sarcomas are rare, why should I refer, does it matter? We are all aware of the fact that most lumps under the skin are benign. Usually they are fatty lumps called lipomas. Small lumps can be sebaceous cysts, and there are many other types, mostly harmless. So, what does it matter if an occasional malignant one slips through and takes a while to be diagnosed? Well, it actually matters a lot; in fact, it’s probably a matter of life or death for the patient with a sarcoma. The fact is that for a sarcoma, the bigger the lump, the worse the outlook. The most aggressive types carry some risk of spreading to other parts of the body, even when they’re less than 5 cm (2”) in size. This means that every delay waiting for a test, falsely reassuring the patient that it is “just a haematoma”, “lymph gland”, “lipoma” etc, means that it is simply getting larger all the while, becoming increasingly likely to spread to other parts of the body, e.g. the lungs, and hence, be incurable.
Where’s the proof that early diagnosis makes a difference? Unfortunately, unlike with common cancers such as breast cancer, the evidence that removing sarcomas at an early stage improves outcome is somewhat hard to find, because it isn’t possible to do a clinical trial. However, every study that has ever looked at all the factors influencing outcome, has concluded that for each individual sarcoma subtype - and they do, of course, vary - tumor size and grade (the degree of aggressiveness) are the most important. Therefore, it seems inconceivable that earlier diagnosis and removal when the disease is smaller would not improve the outlook.
What harm is done if I take it out myself? Sadly, one of the most common ways in which a doctor hears about the diagnosis of sarcoma is when the pathologist rings up to say that the “benign” lump he/she took out under local anaesthetic is actually a sarcoma, and it hasn’t been completely removed. In fact, if you take out a sarcoma and you can actually see it as you go along, then you’ve left some behind. They appear to “shell out” very easily but the so-called “pseudocapsule” is just that, a false capsule or margin; tumour cells extend beyond it. To remove a sarcoma properly, you have to plan the operation based on appropriate imaging and take it out with a good margin of normal tissue all around it. A poor initial operation contaminates the tissues and will sometimes put a scar in the wrong place, which compromises a definitive operation, and makes it more likely that the disease will come back locally.
Among the many horror stories I could relate are the following glaring examples: the first was a patient with sarcoma who was initially treated with antibiotics and then attacked with a scalpel in the mistaken belief that the lump was an abscess – it wasn’t, indeed it was rock hard; the second was a patient with a bleeding tendency who was repeatedly told that the enlarging lump in his thigh was a blood clot. By the time the diagnosis was made, the tumour had spread to the lungs. Clearly, in such cases, inappropriate intervention and delay in diagnosis proved very damaging. In the majority of cases where the tumour is small, a second operation can be performed to remove residual tumour cells without this having a major impact on survival. However, where the second operation reveals residual tumour, there is an increased risk of distant disease spread.
So how can I possibly know if a lump is worrying or not without taking it out?There are some very simply rules. These are the characteristics of a subcutaneous mass that should alert you. Remember that sarcomas can occur anywhere, but the most common site is the leg. A lump that has 2 or more of the following characteristics is potentially malignant and should be treated as such:
Some doctors would add “especially if it is painful,” but this isn’t a very reliable sign, and lack of pain is not necessarily reassuring. So, if you find a lump with any of these characteristics, it should be imaged, (e.g. Magnetic Resonance Imaging, MRI scan) and you should send the patient/have yourself referred to a team that is experienced in the management of sarcomas.
Why refer to a multidisciplinary team in a cancer centre? To diagnose and treat a sarcoma properly, you need to have specialists with the necessary experience in diagnostic radiology, histopathology, surgery, radiation oncology and medical oncology. A scan (usually MRI) is required to identify the size and extent of the disease. A biopsy needs to be done appropriately, and an experienced pathologist is then required to make the diagnosis - these are rare diseases. Surgery needs to be done in a planned way that will ensure complete removal of the tumour, hopefully preserving normal function. Depending on the size, grade, and completeness of resection, radiotherapy may be required. Sometimes this is employed pre-operatively. For some diseases, and in some clinical situations, it is appropriate to use chemotherapy either before or after the operation (or both).
Final message Sarcomas cannot be treated appropriately in the community. If there is doubt as to the nature of a lump, it should be referred to a specialist centre. Follow the simple rules: firm, deep lumps that are growing are rarely benign. Early diagnosis is the key to improving outcomes for patients with sarcoma.
Further reading
V4N1 ESUN Copyright © 2007 Liddy Shriver Sarcoma Initiative. |
