Figure 2: CIP4 protein structure. CIP4 is a member of the F-BAR family of proteins which have been recently described to be involved in sensing and generating membrane curvature. At the N terminus, CIP4 contains an FCH (fes/fps/cip4 homology) domain and coiled-coil region that comprise the F-BAR domain. This domain interacts with the membrane. At the C-terminus, an SH3 domain exists and interacts with WASp, an activator of actin nucleation and polymerization). Protein tyrosine kinases such as Src or Lyn interact via their SH3 domain with a proline-rich motif found in CIP4. Also, CIP4 contains a region that binds only the activated form of Cdc42. Altogether, CIP4 behaves as a scaffolding protein involved in cytoskeletal reorganization.

V5N1 ESUN Copyright © 2008 Liddy Shriver Sarcoma Initiative.