Basic Information on Irinotecan

• Irinotecan is also called Irinotecan hydrochloride trihydrate, CPT-11 and Camptosar

• In the same family as topotecan and exatecan

Basic Information on Temozolomide   

• Temozolomode is also called TMZ, SCHS2.365, NSC 362856, Temodol and Temodar

• Given orally

• FDA label; approved for refractory brain tumors

• 2003 phase 2 trial at Columbia using temozolomide and thalidomide for leiomyosarcoma

Previous Results: Ewing's Sarcoma    

• 2003 abstract for a Phase 2 of temozolomide in Italy; 2/4 partial responses for extraosseous Ewings, 1/4 partial response for Ewing's in a bone

• 2003 abstract for a Phase 1 trial at Utah (Huntsman) and Memphis, TN (St. Jude); 2 partial responses for Ewing's; the unpublished results are much better (5/8 responses in recurrent Ewing's)

Previous Results: Other Cancers  

• 2003 abstract for a Phase 1 trial for recurrent malignant glioma; discusses dosage and side effects

• 2000 abstract and 2000 abstract mouse studies

• 1999 abstract stating that temozolomide is not active in advanced soft tissue sarcomas (Phase 2 trial)

Related Clinical Trial (uses one drug, but not both)   

• Multi-center irinotecan Phase 2 trial for refractory solid tumors in children.