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Refractory Ewing's Sarcoma Sometimes, the biopsy of the resected tumor shows little necrosis (i.e., a low percentage of the cancer cells are dead). If this occurs, or if the tumor continues to grow while the patient is receiving chemotherapy, the term refractory is frequently used. Sometimes, the term is also used when micrometastases (micromets) develop. Micromets are very small mets. Ewing's sarcoma is considered a systemic cancer. A patient may very well have micromets when diagnosed. The treatment may or may not kill them.
Recurrent Ewing's Sarcoma If tumors come back in either the primary site or in a new site (i.e., the cancer has metastasized) once the treatment is done, the patient has recurrent Ewing's sarcoma. This event is also called a relapse.
If Ewing's sarcoma metastasizes, it normally spreads to the lungs, bones and bone marrow. Clinical trials haven't really distinguished between treating recurrent and refractory cases.
Treatment for Recurrent/Refractory Tumors (in no particular order) Topotecan and Cyclophosphamide
High-dose Ifosfamide
Ifosfamide, Carboplatin, and Etoposide
Other Possible Drugs for Refractory/Recurrent Ewing's Sarcoma
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