Unknown Effect

Background Information  

• Manufactured by Human Genome Sciences

• Background science information

• The TRAIL (tumor necrosis factor related apoptosis-inducing ligand) Receptor-1 protein was discovered by Human Genome Sciences. TRAIL Receptor-1 human monoclonal antibody (TRAIL-R1 mAb) specifically recognizes the TRAIL Receptor-1 protein, found on the surface of a number of solid tumor and hematopoietic cancer cells. TRAIL-R1 mAb mimics the activity of native TRAIL. As such, it is considered an agonistic antibody. Binding of TRAIL-R1 mAb to TRAIL Receptor-1 triggers cell death."

Research Results 

• 2002 poster on in vitro and in vivo anti-tumor activity

• 2002 press release for the above talk (easier to understand)

• 2001 abstract stating that apoptosis (cell death) was induced in 7/9 Ewing's sarcoma cell lines by TRAIL (Note: these are cell line results)