Unknown Effect

Agents Having an Unknown Effect

There are a number of chemotherapeutic agents and/or therapeutic approaches currently in trial for Ewing's sarcoma and sarcomas in general. Due to the few patients entered so far, it is not known if these approaches will be successful. Some of the drugs under investigation are listed below (in alphabetical order).

COX-2 inhibitors

• Sample COX-2 inhibitors are Lodine and Celebrex

• Article about the use of COX-2 inhibiting drugs in cancer treatment

ET-743/Ecteinascidin/Yondelis

• Click here for background

Hyperthermy  

• 2002 abstract on hyperthermic isolated lung perfusion chemo using cisplatin for treatment of unresectable lung sarcoma metastasis (case study of 4 patients)

ImmTher 

• M D Anderson Study

Interferons   

• 2002 abstract of a mouse study with interferons with ifosfamide.

mTOR Inhibitors 

• Ariad

Platelet derived growth factor-C 

• 2002 abstract discussing this approach

SU6668 and SU11248  

• 2002 abstract discussing how SU11248 works.

• A number of ASCO abstracts on SU6668 phase 1/dosing: go to the ASCO "search" Abstract page and enter SU6668 in the Search Term field

TRAIL R1  

• Click here for background

Vaccines and immunotherapy 

• Click here for background

• University of Michigan Study

• Dana-Farber Cancer Institute Study

VEGF (Vascular Endothelial Growth Factor) 

• VEGF has important role in the formation of new blood vessels; cells release VEGF, a protein that causes the growth of new blood vessels in a process called angiogenesis.

• Angiogenesis at MSK

• NCI table of angiogenesis inhibitors in clinical trials

• Article giving VEGF background

• CancerIndex VEGF information

• Avastin/bevacizumab background and trial links